- Glibenclamide, also known as
glyburide, is an anti-diabetic drug in a class of medications known as
sulfonylureas, used in the treatment of type II diabetes.
- Glyburide is in a class of drugs
called sulfonylureas.
- It is used to help control blood
sugar levels.
- Treatment with glyburide may
increase the risk of death from cardiovascular disease compared to
treatment of diabetes with diet alone or diet plus insulin.
- The drug works by inhibiting
ATP-sensitive potassium channels in pancreatic beta cells.
- This inhibition causes cell
membrane depolarization, opening of voltage-dependent calcium channels,
thus triggering an increase in intracellular calcium into the beta cell
which stimulates insulin release.
- Inhibition of ATP-sensitive K
channels by an increase in cytosolic ATP4 or a decrease in Mg ADP
and the resultant depolarization are essentially involved in the
physiological mechanisms that lead to insulin secretion from
pancreatic-cells.
- To identify among women with
gestational diabetes mellitus the patient characteristics that
predict treatment failure with glyburide.
- Glyburide was more likely to fail
in women diagnosed earlier in pregnancy, of older age and multiparity,
and with higher fasting glucoses, suggesting that earlier glucose
intolerance and a reduced capacity to respond to an insulin secretagogue
may distinguish this group.
- The whole-cell patch-clamp
technique was used in adult mouse ventricular myocytes at 22°C to study
the transient outward current and its sensitivity to the antimycotics
miconazole and clotrimazole, as well as to glybenclamide.
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Introduction
- Glibenclamide
- Glibenclamide
- Glyburide
Process
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Differential Effects of Glucose and
Glyburide on Energetics and Na+ Levels of HC9 Cells
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Preparation of nano crystals of
glyburide by high energy controlled salting out process and their
characterization
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Rosiglitazone, But Not Glyburide,
Reduces Circulating Proinsulin and the Proinsulin
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Effects Of The Sulfonylurea Glyburide
On Catalase Activities in Streptozotocin-Induced Diabetic Rat
Muscle
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Synthesis of benzoic acid and
its analoguous labeling precursor
Application
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Effect of glyburide and w3 fatty acid
dietary supplements on glucose and lipid metabolism in patients with
non- insulin dependent diabetes mellitus
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Effects of the Combination of a
Dipeptidyl Peptidase IV Inhibitor and an Insulin Secretagogue on Glucose
and Insulin Levels in Mice and Rats
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Mesenteric Arterial Relaxation to
Calcitonin Gene-Related Peptide Is Increased During Pregnancy and by Sex
Steroid Hormones1
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A New Generation of
Hypoglycemics
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Stimulation of Bile Duct Epithelial
Secretion by Glybenclamide in Normal and Cholestatic Rat Liver
Msds
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Glyburide
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Safety data
for glyburide
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Glyburide Msds
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Glybenclamide
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Report
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ATP-binding Cassette Transporter
A1 Functions as a Cholesterol Efflux Regulatory Protein
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Effect of indomethacin on electrical
field stimulation-induced contractions of isolated transverse and
longitudinal rat gastric fundus strips
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Glucose-dependent, mediated ATP efflux
from Saccharomyces cerevisiae
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Separately Inherited Defects in
Insulin Exocytosis and -Cell Glucose Metabolism Contribute to Type 2
Diabetes
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Predictors of Glyburide Failure in the
Treatment of Gestational Diabetes
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Role of K+ATP channels in coronary
vasodilation during exercise
Patent &
Technology
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Glyburide composition
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Synergistic effect of glyburide and
milrinone
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Composition and method for treating
diabetes
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Spray-dried lactose formulation of
micronized glyburide
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Pharmaceutical compositions for oral
use, containing, in combination, met formin and glyclazide
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Suppression of Transient Outward
Potassium Currents in Mouse Ventricular Myocytes by Imidazole
Antimycotics and by Glybenclamide
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31P and 23Na NMR Spectroscopy
Demonstrate Glyburide Effects on Bioenergetics and Na+ Transport in
Pancreatic Beta-HC9 Cells
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